“anti-diabetic Properties of Kalanchoe Pinnata (lam.) Pers. in Alloxan Induced Diabetic Mice”
نویسندگان
چکیده
INTRODUCTON The use of plants for treating diseases is as old as the human generations. Popular observations on the use and efficacy of medicinal plants significantly contribute to the disclosure of their therapeutic properties. India is the gateway of medicinal plants in the world with a rich source for food and medicine. From past several decades more importance are given to the research on medicinal and some plants were already tested for ABSTRACT Kalanchoe pinnata is a succulent perennial plant which is commonly known as ‘air plant’. The anti-diabetic activity of Kalanchoe pinnata leaf extracts was investigated in alloxan induced diabetic swiss albino mice. A comparison was made between the action of different extracts of K. pinnata and a known antidiabetic drug glibenclamide. Hypoglycemic activity, determination of blood glucose by glucose oxidase method and total cholesterol was performed in experimental diabetic mice. Dose selection was made on the basis of acute oral toxicity study as per OECD guidelines. K. pinnata ethyl acetate extract (500 mg) and aqueous extract (500 mg) blood glucose levels of these extracts on 14th day of the study were 114 and 121 mg/dL. In alloxan-induced model, blood glucose levels of these extracts on 14th day of the study were 355 mg/dL and 98.67 mg/dL in comparison of diabetic control. In blood serum glucose level extracts of ethyl acetate (500 mg) of K. pinnata exhibited 321 mg/dL at initial day and finally the blood serum glucose reduces to 117 mg/dL. Whereas alloxan treated showed a maximum blood serum glucose level of 333, 346 and 367 on 1, 7 and 14 days respectively. These ethyl acetate and aqueous extracts of K. pinnata also showed decreased cholesterol levels when compared to alloxan treated diabetic mice. In all these experiments, extracts of K. pinnata proved to be the potential antidiabetic drug.
منابع مشابه
Analgesic and neuropharmacological activities of the ethanolic extract of leaves of Kalanchoe pinnata (Lam.)Pers. in Swiss Albino mice
متن کامل
Anti-Diabetic Activity of Terminalia catappa Linn. Leaf Extracts in Alloxan-Induced Diabetic Rats
In view of suggested anti diabetic potential, effect of aqueous and cold extracts of Terminalia Catappa Linn (Combretaceae) leaves, on fasting blood sugar levels and serum biochemical analysis in alloxan-induced diabetic rats was investigated. All the extracts of Terminalia Catappa produced a significant anti diabetic activity at dose levels of 1/5th of their lethal doses. Concurrent histologic...
متن کاملEvaluation of Nephroprotective and Antidiabetic Effects of Gundelia tournefortii Aqueous Extract on Diabetic Nephropathy in Male Mice
Background and objectives: Due to the rapid growth of global interest in use of ethno medicinal plants, their effects and safety assessment have become substantial. Gundelia tournefortii has been used as antioxidant, anti-inflammatory, antipyretic, anti-fungal, and antibacterial agent. In the present study, nephrprotective and antidiabetic properties of Gundelia to...
متن کاملEvaluation of Antidiabetic Activity of a Polyherbal Formulation in Alloxan Induced Diabetic Rats
Objective of the study was to assess the antidiabetic activity of a polyherbal formulation in alloxan induced diabetic rats. Methods: The antidiabetic activity of a polyherbal formulation in alloxan induced diabetic rats was assessed using Alloxan βcytotoxin induced chemical diabetes in a wide variety of wister albino rats. Result: The polyherbal formulation contain the following plants leaves ...
متن کاملAnti-hyperglycemic Effects of Saffron and its Active Constituents, Crocin and Safranal, in Alloxan-Induced Diabetic Rats
Background: Saffron is the dried stigmata of the flowers of saffron (Crocus sativus L., Iridaceae). Saffron and its major active constituents, crocin (crocetin glycoside), crocetin and safranal, have a variety of pharmacological effects including high antioxidant properties and crocetin has insulin sensitizing effect possibly due to its antioxidant activity. Oral crocin is not absorbed and is h...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2017